Memory-Enhancing Effect of a Supercritical Carbon Dioxide Fluid Extract of the Needles of Abies koreana on Scopolamine-Induced Amnesia in Mice

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  • KIM Kanghyun
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
  • BU Youngmin
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
  • JEONG Seungil
    Division of Biomedicinal Chemistry and Cosmetics, College of Science and Technology, Mokwon University
  • LIM Jongpil
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
  • KWON Youngan
    College of Science and Engineering, Woosuk University
  • CHA Dong Seok
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
  • KIM Jinmo
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
  • JEON Sora
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
  • EUN Jaesoon
    Department of Pharmacy, College of Pharmacy, Woosuk University
  • JEON Hoon
    Department of Oriental Pharmacy, College of Pharmacy, Woosuk University

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  • Memory-Enhancing Effect of a Supercritical Carbon Dioxide Fluid Extract of the Needles of<i>Abies koreana</i>on Scopolamine-Induced Amnesia in Mice

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Abstract

Abies koreana Wilson (A. koreana) is a shrub or broadly pyramidal evergreen tree endemic in the mountainous regions of South Korea. We obtained the essential oil (EO) from alpine needle leaves of A. koreana by the supercritical fluid extraction (SFE) method. EO was analyzed by gas chromatography–mass spectrometry (GC–MS), and 68 compounds were identified constituting 95.66% of the oil. The major components were elemol (11.17%), terpinen-4-ol (9.77%), sabinene (8.86%), 10(15)-cadien-4-ol (7.16%), α-terpineol (6.13%), α-pinene (6.07%) and γ-terpinene (4.71%). To investigate the memory-enhancing effects, we conducted a passive avoidance test using a scopolamine (1 mg/kg, ip)-induced amnesia mouse model. A peritoneal injection of EO from A. koreana (100 mg/kg) showed a memory enhancing effect of 72.7% compared with the control. These results suggest that EO of A. koreana may be a useful therapeutic agent against such amnesia-inducing diseases as Alzheimer and vascular dementia.

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