Oral Administration of an Immunostimulatory DNA Sequence from<i>Bifidobacterium longum</i>Improves Th1/Th2 Balance in a Murine Model

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  • TAKAHASHI Noritoshi
    Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
  • KITAZAWA Haruki
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
  • IWABUCHI Noriyuki
    Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
  • XIAO Jin-Zhong
    Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
  • MIYAJI Kazuhiro
    Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
  • IWATSUKI Keiji
    Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
  • SAITO Tadao
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University

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  • Oral Administration of an Immunostimulatory DNA Sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model

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We have reported the antiallergic activities of the immunostimulatory oligodeoxynucleotide (ODN) BL07S, identified from genomic DNA of Bifidobacterium longum BB536 from in vitro and in vivo studies. The present study evaluated the efficiency of ODN BL07S in preventing allergic responses by oral administration. Oral administration of BL07S suppressed serum ovalbumin (OVA)-specific immunoglobulin (Ig) E levels and improved the OVA-specific IgG2a/IgG1 ratio. ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics.

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