A New Double-Stranded RNA Binding Protein (DRBP-120) Is Associated with Double-Stranded RNA-Activated Protein Kinase (PKR)
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Double-stranded RNA-activated protein kinase (PKR) plays an important role in interferon-induced antiviral responses, and is also involved in intracellular signaling pathways, including the apoptosis, proliferation, and transcription pathways. In this study, a new 120-kDa PKR-associated protein designated double-stranded RNA binding protein (DRBP)-120 was identified using co-immunoprecipitation with anti-PKR antiserum and two-dimensional electrophoresis. Furthermore, DRBP-120 is a double-stranded RNA (dsRNA)-binding protein, and it was detected in both the cytoplasm and the nucleus of HeLa cells associated with PKR.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(7), 1717-1723, 2006-07-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry