A New Double-Stranded RNA Binding Protein (DRBP-120) Is Associated with Double-Stranded RNA-Activated Protein Kinase (PKR)

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  • WATANABE Shuji
    Department of Physiology, School of Medicine, Iwate Medical University
  • YAMASHITA Tetsuro
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • TAIRA Hideharu
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University

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  • New Double Stranded RNA Binding Protein DRBP 120 Is Associated with Double Stranded RNA Activated Protein Kinase PKR

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Abstract

Double-stranded RNA-activated protein kinase (PKR) plays an important role in interferon-induced antiviral responses, and is also involved in intracellular signaling pathways, including the apoptosis, proliferation, and transcription pathways. In this study, a new 120-kDa PKR-associated protein designated double-stranded RNA binding protein (DRBP)-120 was identified using co-immunoprecipitation with anti-PKR antiserum and two-dimensional electrophoresis. Furthermore, DRBP-120 is a double-stranded RNA (dsRNA)-binding protein, and it was detected in both the cytoplasm and the nucleus of HeLa cells associated with PKR.

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