Simple Synthesis of Enantiomerically Pure Sauriols A and B

  • MORI Naoki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • WATANABE Hidenori
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • KITAHARA Takeshi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo Laboratory of Natural Product Chemistry, Center for Basic Research, The Kitasato Institute

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Abstract

Sauriols A and B belong to a class of diarylbutane-lignans and exhibit antifeedant activity. We succeeded in the first synthesis of sauriols A and B by using a simple and efficient asymmetric dimerization of a cinnamic acid derivative as the key step.

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