Polyphenolic Constituent Structures of<i>Zanthoxylum piperitum</i>Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant<i>Staphylococcus aureus</i>
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- KUSUDA Miwako
- Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- INADA Kazutoshi
- Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- OGAWA Tomo-omi
- Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- YOSHIDA Takashi
- Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- SHIOTA Sumiko
- Department of Pathogenic Microbiology, School of Pharmacy, Shujitsu University
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- TSUCHIYA Tomofusa
- Department of Microbiology, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- HATANO Tsutomu
- Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
書誌事項
- タイトル別名
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- Polyphenolic Constituent Structures of Zanthoxylum piperitum Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant Staphylococcus aureus
- Polyphenolic constituent structures of <italic>Zanthoxylum piperitum</italic> fruit and the antibacterial effects of its polymeric procyanidin on methicillin-resistant <italic>Staphylococcus aureus</italic>
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抄録
Zanthoxylum piperitum (Rutaceae) is used as a spice and a natural medicine in Japan. Our study found that ZP-CT-A, a polymeric proanthocyanidin purified from the fruit of this species, noticeably decreased the minimum inhibitory concentrations of β-lactam antibiotics for methicillin-resistant Staphylococcus aureus (MRSA). The structure of ZP-CT-A was characterized on the basis of 13C NMR and size exclusion chromatographic data and the results of thiolytic degradation. A mechanistic study of the effects of ZP-CT-A indicated that it suppressed the activity of β-lactamase and largely decreased the stability of the bacterial cell membrane of MRSA, as shown by a reduction in the tolerance of MRSA to low osmotic pressure and high ionic strength solutions.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (6), 1423-1431, 2006
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456285568
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- NII論文ID
- 10018530183
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD28XmslWkur8%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7958962
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- PubMed
- 16794323
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可