Hepatoprotective Effects of Purple Potato Extract against D-Galactosamine-Induced Liver Injury in Rats

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著者

    • Han Kyu-Ho HAN Kyu-Ho
    • Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
    • SEKIKAWA Mitsuo
    • Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
    • NODA Takahiro
    • Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
    • YAMAUCHI Hiroaki
    • Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
    • HASHIMOTO Makoto
    • Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
    • CHIJI Hideyuki
    • Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women's College
    • FUKUSHIMA Michihiro
    • Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine

抄録

We investigated the hepatoprotective effect of purple potato extract (PPE) against <small>D</small>-galactosamine (GalN)-induced liver injury in rats. PPE (400 mg) was administered once daily for 8 d, and then GalN (250 mg/kg of body weight) was injected at 22 h before the rats were killed. Serum tumor necrosis factor alpha (TNF-α), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and asparate aminotranferase (AST) levels increased significantly after injection of GalN, but PPE inhibited GalN-induced alterations in serum TNF-α, LDH, ALT, and AST levels. Hepatic lipid peroxide and glutathione levels in the control + GalN group were higher and lower respectively than those in the control group, and those in the PPE + GalN group did not differ from that in the control group. The lipid peroxide level in hepatic microsomes treated with 2,2′-azobis (2-amidinopropane) dihydrochloride in the PPE group was significantly lower than that in the control group. This suggests that PPE has hepatoprotective effects against GalN-induced hepatotoxicity <I>via</I> inhibition lipid peroxidation and/or inflammation in rats.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(6), 1432-1437, 2006-06-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018530216
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    7958972
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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