Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product

• USUI Teruyuki

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

• WATANABE Hirohito

  Department of Life Sciences, Faculty of Agriculture, Meiji University

• HAYASE Fumitaka

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

抄録

We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and N^α-acetylarginine. A major product was identified as N^α-acetyl-N^δ-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 70 (6), 1496-1498, 2006

  公益社団法人 日本農芸化学会

キーワード

• glyceraldehyde
• advanced glycation end product
• glycation
• Maillard reaction
• methylglyoxal

詳細情報

• CRID: 1390001206479586176
• NII論文ID: 10018530468
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.50584
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 7959061
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7959061
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.50584
• 本文言語コード: en
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