Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product
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We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and <I>N</I><SUP>α</SUP>-acetylarginine. A major product was identified as <I>N</I><SUP>α</SUP>-acetyl-<I>N</I><SUP>δ</SUP>-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(6), 1496-1498, 2006-06-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry