Repression of Secondary Metabolite Production by Exogenous cAMP in Monascus
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The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in <I>Monascus</I>. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production (Miyake, T., <I>et al.</I>, <I>Biosci. Biotechnol. Biochem.</I>, <B>70</B>, 1154–1159 (2006)) was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(6), 1521-1523, 2006-06-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry