Repression of Secondary Metabolite Production by Exogenous cAMP in Monascus
The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in <I>Monascus</I>. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production (Miyake, T., <I>et al.</I>, <I>Biosci. Biotechnol. Biochem.</I>, <B>70</B>, 1154–1159 (2006)) was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.
- Bioscience, biotechnology, and biochemistry
Bioscience, biotechnology, and biochemistry 70(6), 1521-1523, 2006-06-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry