Repression of Secondary Metabolite Production by Exogenous cAMP in Monascus

• MIYAKE Tsuyoshi

  Industrial Technology Center of Okayama Prefecture

• ZHANG Ming-Yong

  Industrial Technology Center of Okayama Prefecture Japan Society for the Promotion of Science

• KONO Isato

  Industrial Technology Center of Okayama Prefecture

• NOZAKI Nobuyuki

  Industrial Technology Center of Okayama Prefecture

• SAMMOTO Hiroyuki

  Industrial Technology Center of Okayama Prefecture

Bibliographic Information

Other Title

• Repression of Secondary Metabolite Production by Exogenous cAMP in<i>Monascus</i>

Abstract

The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in Monascus. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production (Miyake, T., et al., Biosci. Biotechnol. Biochem., 70, 1154–1159 (2006)) was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (6), 1521-1523, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• <I>Monascus</I>
• secondary metabolite production
• cAMP
• repression
• mutant MK-1

Details

• CRID: 1390001206479590016
• NII Article ID: 10018530555
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.50686
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7959287
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7959287
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.50686
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed