Possible Involvement of Calcium Signaling Pathways in<scp>L</scp>-Leucine-Stimulated Protein Synthesis in L6 Myotubes

• MIURA Yutaka

  Department of Applied Biological Science, Tokyo Noko University

• NAKAZAWA Taro

  Department of Applied Biological Science, Tokyo Noko University

• YAGASAKI Kazumi

  Department of Applied Biological Science, Tokyo Noko University

書誌事項

タイトル別名

• Possible Involvement of Calcium Signaling Pathways in L-Leucine-Stimulated Protein Synthesis in L6 Myotubes

抄録

L-Leucine is known to stimulate protein synthesis in L6 myotubes. In the present study, we examined the possible involvement of calcium signaling pathways in the stimulation of protein synthesis induced by L-leucine in L6 myotubes. After 16 h of treatment with L-leucine-depleted medium, the re-addition of L-leucine for 4 h augmented protein synthesis by about 50% as compared with an L-leucine-depleted control. Ryanodine receptor antagonists almost completely abolished the stimulatory effect of L-leucine, while IP₃ receptor antagonists showed partial inhibition when added simultaneously with L-leucine. These results suggest the possibility that calcium signaling pathways are involved in L-leucine-stimulated protein synthesis.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 70 (6), 1533-1536, 2006

  公益社団法人 日本農芸化学会

キーワード

• <small>L</small>-leucine
• protein synthesis
• calcium
• myotubes

詳細情報

• CRID: 1390282681456314752
• NII論文ID: 10018530595
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.60081
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 7959151
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7959151
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60081
• 本文言語コード: en
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