Possible Involvement of Calcium Signaling Pathways in L-Leucine-Stimulated Protein Synthesis in L6 Myotubes

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<small>L</small>-Leucine is known to stimulate protein synthesis in L6 myotubes. In the present study, we examined the possible involvement of calcium signaling pathways in the stimulation of protein synthesis induced by <small>L</small>-leucine in L6 myotubes. After 16 h of treatment with <small>L</small>-leucine-depleted medium, the re-addition of <small>L</small>-leucine for 4 h augmented protein synthesis by about 50% as compared with an <small>L</small>-leucine-depleted control. Ryanodine receptor antagonists almost completely abolished the stimulatory effect of <small>L</small>-leucine, while IP<SUB>3</SUB> receptor antagonists showed partial inhibition when added simultaneously with <small>L</small>-leucine. These results suggest the possibility that calcium signaling pathways are involved in <small>L</small>-leucine-stimulated protein synthesis.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(6), 1533-1536, 2006-06-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018530595
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    09168451
  • NDL 記事登録ID
    7959151
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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