Possible Involvement of Calcium Signaling Pathways in L-Leucine-Stimulated Protein Synthesis in L6 Myotubes

• MIURA Yutaka

  Department of Applied Biological Science, Tokyo Noko University

• NAKAZAWA Taro

  Department of Applied Biological Science, Tokyo Noko University

• YAGASAKI Kazumi

  Department of Applied Biological Science, Tokyo Noko University

Bibliographic Information

Other Title

• Possible Involvement of Calcium Signaling Pathways in<scp>L</scp>-Leucine-Stimulated Protein Synthesis in L6 Myotubes

Abstract

L-Leucine is known to stimulate protein synthesis in L6 myotubes. In the present study, we examined the possible involvement of calcium signaling pathways in the stimulation of protein synthesis induced by L-leucine in L6 myotubes. After 16 h of treatment with L-leucine-depleted medium, the re-addition of L-leucine for 4 h augmented protein synthesis by about 50% as compared with an L-leucine-depleted control. Ryanodine receptor antagonists almost completely abolished the stimulatory effect of L-leucine, while IP₃ receptor antagonists showed partial inhibition when added simultaneously with L-leucine. These results suggest the possibility that calcium signaling pathways are involved in L-leucine-stimulated protein synthesis.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (6), 1533-1536, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• <small>L</small>-leucine
• protein synthesis
• calcium
• myotubes

Details

• CRID: 1390282681456314752
• NII Article ID: 10018530595
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.60081
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7959151
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7959151
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60081
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed