Down-Regulation of<i>mdr1b</i>mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride

• KOBAYASHI-HATTORI Kazuo

  Division of Microbiology, National Institute of Health Sciences

• WATANABE Takahiro

  Division of Food, National Institute of Health Sciences

• KIMURA Kimiko

  Department of Veterinary Medical Sciences, The University of Tokyo

• SUGITA-KONISHI Yoshiko

  Division of Microbiology, National Institute of Health Sciences

書誌事項

タイトル別名

• Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride

抄録

We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml) ad libitum from the start of pregnancy to weaning or from parturition to weaning. Exposure via the placenta and lactation significantly reduced the renal mdr1b level in offspring. Exposure to TBTC through the mother might impair the exclusion system of toxic compounds in offspring.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 70 (5), 1242-1245, 2006

  公益社団法人 日本農芸化学会

キーワード

• tributyltin chloride
• <I>mdr1b</I>
• offspring
• placenta
• lactation

詳細情報

• CRID: 1390282681453736576
• NII論文ID: 10018531585
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70.1242
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 7926453
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7926453
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.1242
• Web Site: https://search.jamas.or.jp/link/ui/2007029340
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可