Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride
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- KOBAYASHI-HATTORI Kazuo
- Division of Microbiology, National Institute of Health Sciences
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- WATANABE Takahiro
- Division of Food, National Institute of Health Sciences
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- KIMURA Kimiko
- Department of Veterinary Medical Sciences, The University of Tokyo
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- SUGITA-KONISHI Yoshiko
- Division of Microbiology, National Institute of Health Sciences
Bibliographic Information
- Other Title
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- Down-Regulation of<i>mdr1b</i>mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride
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Abstract
We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml) ad libitum from the start of pregnancy to weaning or from parturition to weaning. Exposure via the placenta and lactation significantly reduced the renal mdr1b level in offspring. Exposure to TBTC through the mother might impair the exclusion system of toxic compounds in offspring.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (5), 1242-1245, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681453736576
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- NII Article ID
- 10018531585
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7926453
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed