Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride

• KOBAYASHI-HATTORI Kazuo

  Division of Microbiology, National Institute of Health Sciences

• WATANABE Takahiro

  Division of Food, National Institute of Health Sciences

• KIMURA Kimiko

  Department of Veterinary Medical Sciences, The University of Tokyo

• SUGITA-KONISHI Yoshiko

  Division of Microbiology, National Institute of Health Sciences

Bibliographic Information

Other Title

• Down-Regulation of<i>mdr1b</i>mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride

Abstract

We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml) ad libitum from the start of pregnancy to weaning or from parturition to weaning. Exposure via the placenta and lactation significantly reduced the renal mdr1b level in offspring. Exposure to TBTC through the mother might impair the exclusion system of toxic compounds in offspring.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (5), 1242-1245, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• tributyltin chloride
• <I>mdr1b</I>
• offspring
• placenta
• lactation

Details

• CRID: 1390282681453736576
• NII Article ID: 10018531585
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.70.1242
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7926453
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7926453
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.1242
• Web Site: https://search.jamas.or.jp/link/ui/2007029340
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed