Biotransformation of (-)-Menthone by Human Liver Microsomes
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The aim of the current study was to investigate the metabolism of (−)-menthone by liver microsomes of humans. (−)-Menthone (<B>1</B>) was metabolized to (+)-neomenthol (<B>2</B>) (3-reduction) and 7-hydroxymenthone (<B>3</B>) by human liver microsomes. The metabolites formed were analyzed on GC and GC–MS. Kinetic analysis showed that <I>K</I><SUB>m</SUB> and <I>V</I><SUB>max</SUB> values for the metabolized (−)-menthone to respective (+)-neomenthol and 7-hydroxymenthone by liver microsomes of human sample HG70 were 0.37 m<small>M</small> and 4.91 nmol/min/mg protein and 0.07 m<small>M</small> and 0.71 nmol/min/mg protein.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(5), 1259-1261, 2006-05-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry