Biotransformation of (-)-Menthone by Human Liver Microsomes

• MIYAZAWA Mitsuo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• NAKANISHI Kyousuke

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

Bibliographic Information

Other Title

• Biotransformation of (−)-Menthone by Human Liver Microsomes

Abstract

The aim of the current study was to investigate the metabolism of (−)-menthone by liver microsomes of humans. (−)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC–MS. Kinetic analysis showed that K_m and V_max values for the metabolized (−)-menthone to respective (+)-neomenthol and 7-hydroxymenthone by liver microsomes of human sample HG70 were 0.37 mM and 4.91 nmol/min/mg protein and 0.07 mM and 0.71 nmol/min/mg protein.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (5), 1259-1261, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• microsomes
• (−)-menthone
• kinetic analysis

Details

• CRID: 1390282681453711744
• NII Article ID: 10018531679
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.70.1259
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7926528
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7926528
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.1259
• Web Site: https://search.jamas.or.jp/link/ui/2007029343
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed