Production of Three<i>O</i>-Methhylated Esculetins with<i>Escherichia coli</i>Expressing<i>O</i>-Methyltransferase from Poplar

  • KIM Bong Gyu
    Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University
  • LEE Youngshim
    Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University
  • HUR Hor-Gil
    Department of Environmental Science and Engineering and International Environmental Research Center, Gwangju Institute of Science and Technology
  • LIM Yoongho
    Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University
  • AHN Joong-Hoon
    Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University

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  • Production of Three O-Methhylated Esculetins with Escherichia coli Expressing O-Methyltransferase from Poplar

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O-Methyltransferase, POMT-9 was expressed in Escherichia coli. HPLC analysis of reaction products revealed three peaks corresponding to isoscopoletin, scopoletin, and scoparone, and their structures were determined using NMR. Biotransformation of esculetin with E. coli expressing POMT-9 generated scopoletin, isoscopoletin, and scoparone at 30.3, 21, and 31 μM respectively. POMT-9 is the first O-methyltransferase that produces three different O-methylated products.

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