Restriction of the in Vitro Formation of Angiotensin II by Leucinyl-Arginyl-Tryptophan, a Novel Peptide with Potent Angiotensin I-Converting Enzyme Inhibitory Activity
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Leucinyl-arginyl-tryptophan (LRW) is a new peptide inhibitor of the angiotensin converting enzyme (ACE) that was previously predicted through quantitative structure-activity relationship modeling. LRW inhibited ACE activity in a competitive manner with a higher <I>K</I><SUB>m</SUB> value in the presence of the peptide, and the <I>in vitro</I> formation of angiotensin II by ACE was significantly reduced in the presence of LRW up to 60 min of incubation time.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(5), 1277-1280, 2006-05-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry