Hepatoprotective Effects of Whey Protein on D-Galactosamine-Induced Hepatitis and Liver Fibrosis in Rats
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- KUME Hisae
- Department of Nutritional Research, Food Science Institute, Meiji Dairies Corporation
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- OKAZAKI Keiko
- Department of Nutritional Research, Food Science Institute, Meiji Dairies Corporation
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- SASAKI Hajime
- Department of Nutritional Research, Food Science Institute, Meiji Dairies Corporation
Bibliographic Information
- Other Title
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- Hepatoprotective Effects of Whey Protein on<scp>D</scp>-Galactosamine-Induced Hepatitis and Liver Fibrosis in Rats
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Abstract
The hepatoprotective effects of whey protein on two injections of D-galactosamine (300 mg/kg, i.p.) were investigated in rats fed a modified AIN-93M diet formulated with a protein source of casein or whey for 16 d. The whey protein-containing diet clearly suppressed an increase in plasma alanine and aspartate aminotransferase activity, lactate dehydrogenase and bilirubin, which are hepatitis markers, and also hyaluronic acid, a fibrosis marker. In addition, it suppressed histopathological signs of portal fibrosis, bile duct proliferation, and perivenular sclerosis. These results suggest that supplementation with whey protein can help prevent the development of hepatitis and portal fibrosis.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (5), 1281-1285, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681453712896
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- NII Article ID
- 10018531764
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7926651
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed