The Region in a Subunit of the Aspergillus CCAAT-Binding Protein Similar to the HAP4p-Recruiting Domain of Saccharomyces cerevisiae Hap5p Is Not Essential for Transcriptional Enhancement
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The CCAAT-binding complex in <I>Aspergillus</I> species, known as the Hap complex, consists of at least three subunits, HapB, HapC, and HapE. Each Hap subunit contains an evolutionarily conserved core domain. In this study, a series of the truncated gene, which encodes the HapE subunit of <I>Aspergillus oryzae</I>, was constructed to survey the regions essential for the transcriptional enhancement of fungal genes. It was revealed that the non-conserved regions and the conserved region similar to the Hap4p recruiting domain of <I>Saccharomyces cerevisiae</I> were not necessary for Hap complex-mediated transcriptional enhancement.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(4), 782-787, 2006-04-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry