Soy Protein Suppresses Gene Expression of Acetyl-CoA Carboxylase Alpha from Promoter PI in Rat Liver

DOI Web Site Web Site 1 Citations 46 References
  • AOKI Hisa
    Course of the Science of Bioresources, The United Graduate School of Agricultural Sciences, Iwate University
  • KIMURA Kumi
    Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
  • IGARASHI Kiharu
    Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University
  • TAKENAKA Asako
    Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

Search this article

Abstract

Dietary soy protein isolate (SPI) reduces hepatic lipogenesis by suppressing gene expression of lipogenic enzymes, including acetyl-CoA carboxylase (ACC). In order to elucidate the mechanism of this regulation, the effect of dietary SPI on promoter (PI and PII) specific gene expression of ACC alpha was investigated. Rats were fed experimental diets containing SPI or casein as a nitrogen source. SPI feeding decreased the hepatic contents of total ACC mRNA as well as triglyceride (TG) content, but dietary SPI affected the amount of sterol-regulatory element binding protein (SREBP)-1 mRNA and protein very little. The amount of ACC mRNA transcribed from PII promoter containing SRE was not significantly affected by dietary protein, while a significant decrease in PI-generated ACC mRNA content was observed in rats fed the SPI diet. These data suggest that SPI feeding decreased the hepatic contents of ACC alpha mRNA mainly by regulating PI promoter via a nuclear factor(s) other than SREBP-1.

Journal

Citations (1)*help

See more

References(46)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top