Changes in the Mutagenic and Estrogenic Activities of 17β-Estradiol after Treatment with Nitrite

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著者

    • Masuda Shuichi MASUDA Shuichi
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • Terashima Yumeko TERASHIMA Yumeko
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • Sano Ayako [他] SANO Ayako
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • OKADA Masaki
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • DEGUCHI Yuya
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • TOYOIZUMI Tomoyasu
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • KUMAZAWA Shigenori
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • KAMIHIRA Miya
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • YOSHIOKA Hisashi
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • TERAO Yoshiyasu
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka
    • KINAE Naohide
    • Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE program in the 21^<st> Century, University of Shizuoka

抄録

We determined the changes in the mutagenic and estrogenic activities of 17β-estradiol after a nitrite treatment. Nitrite-treated 17β-estradiol showed mutagenic activities toward <I>Salmonella typhimurium</I> strains TA 100 and TA 98. We confirmed that nitrite-treated 17β-estradiol generated radicals from the results of an analysis of electron spin resonance. By applying an instrumental analysis, we identified 2-nitro-17β-estradiol to have been formed in the reaction mixture. 2-Nitro-17β-estradiol did not exhibit mutagenic activities toward <I>Salmonella typhimurium</I> strains, suggesting that other mutagens might have been formed in the reaction mixture. The clastogenic properties of nitrite-treated 17β-estradiol and 2-nitro-17β-estradiol were analyzed by a micronucleus test with male ICR mice. Nitrite-treated 17β-estradiol and 2-nitro-17β-estradiol induced a significantly higher frequency of micronucleated reticulocytes in mice. The estrogenic activity of 2-nitro-17β-estradiol was found to be lower than that of 17β-estradiol. These data suggest that a daily oral intake of 17β-estradiol and nitrite might induce the formation of mutagenic compounds in our body.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(4), 890-896, 2006-04-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018532323
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    7899685
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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