Enhanced Hypoglycemic Activity Following Intratracheal Administration of Insulin Microcrystal Suspension with Injection Adjuvant
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The pulmonary route appears to be the most attractive alternative for non-invasive systemic delivery of insulin. We have shown the feasibility of insulin microcrystals as a long-acting formulation for pulmonary delivery. In this study, we examined the effects of adjuvant for pulmonary formulations of insulin, such as protamine, zinc, and glycerol. In an <I>in vivo</I> experiment with rats, only zinc enhanced the hypoglycemic effect of insulin microcrystals, with 17% of minimum reductions in blood glucose (%MRBG) and a 44% decrement in the blood glucose level (D%<SUB>9h</SUB>).
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(4), 1003-1005, 2006-04-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry