Enhanced Hypoglycemic Activity Following Intratracheal Administration of Insulin Microcrystal Suspension with Injection Adjuvant

• LEE Hyun-Kyung

  School of Life Sciences and Biotechnology, Korea University

• KWON Jai-Hyun

  School of Life Sciences and Biotechnology, Korea University

• PARK Sang-Ha

  School of Life Sciences and Biotechnology, Korea University

• KIM Chan-Wha

  School of Life Sciences and Biotechnology, Korea University

Abstract

The pulmonary route appears to be the most attractive alternative for non-invasive systemic delivery of insulin. We have shown the feasibility of insulin microcrystals as a long-acting formulation for pulmonary delivery. In this study, we examined the effects of adjuvant for pulmonary formulations of insulin, such as protamine, zinc, and glycerol. In an in vivo experiment with rats, only zinc enhanced the hypoglycemic effect of insulin microcrystals, with 17% of minimum reductions in blood glucose (%MRBG) and a 44% decrement in the blood glucose level (D%_9h).

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (4), 1003-1005, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• insulin
• microcrystal
• instillation
• lung
• adjuvant

Details

• CRID: 1390001206476188928
• NII Article ID: 10018532778
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.70.1003
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7899951
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7899951
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.1003
• Web Site: https://search.jamas.or.jp/link/ui/2007004470
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed