Cytotoxic Activity toward KB Cells of 2-Substituted Naphtho[2,3-b]furan-4,9-diones and Their Related Compounds
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We investigated the cytotoxic activity of 2-substituted naphtho[2,3-<I>b</I>]furan-4,9-diones. We have previously synthesized 33 types of 2-substituted and related compounds, and the cytotoxic activity of these compounds was then examined by a KB cell culture assay. 2-(3-Furanoyl)benzoic acids and 1,4-naphthoquinones had no activity. 2-Acetyl-4,9-dimethoxynaphtho[2,3-<I>b</I>]furan <B>4</B> showed low activity. However, parent naphtho[2,3-<I>b</I>]furan-4,9-dione <B>2</B> and most 2-substituted derivatives exhibited cytotoxic activity. The parent structure was therefore for cytotoxicity. 2-Formylnaphtho[2,3-<I>b</I>]furan-4,9-dione <B>11</B> had particularly potent activity (ED<SUB>50</SUB>=0.09 μg/ml).
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(4), 1009-1012, 2006-04-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry