Cytotoxic Activity toward KB Cells of 2-Substituted Naphtho[2,3-b]furan-4,9-diones and Their Related Compounds
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- OGAWA Masayuki
- Faculty of Pharmaceutical Sciences, Josai University
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- KOYANAGI Jyunichi
- Faculty of Pharmaceutical Sciences, Josai University
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- SUGAYA Aiko
- Faculty of Pharmaceutical Sciences, Josai University
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- TSUDA Tadashi
- Faculty of Pharmaceutical Sciences, Josai University
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- OHGUCHI Hiromi
- Faculty of Pharmaceutical Sciences, Josai University
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- NAKAYAMA Kouji
- Faculty of Pharmaceutical Sciences, Josai University
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- YAMAMOTO Katsumi
- Faculty of Pharmaceutical Sciences, Josai University
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- TANAKA Akira
- Faculty of Pharmaceutical Sciences, Josai University
Bibliographic Information
- Other Title
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- Cytotoxic Activity toward KB Cells of 2-Substituted Naphtho[2,3-<i>b</i>]furan-4,9-diones and Their Related Compounds
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Abstract
We investigated the cytotoxic activity of 2-substituted naphtho[2,3-b]furan-4,9-diones. We have previously synthesized 33 types of 2-substituted and related compounds, and the cytotoxic activity of these compounds was then examined by a KB cell culture assay. 2-(3-Furanoyl)benzoic acids and 1,4-naphthoquinones had no activity. 2-Acetyl-4,9-dimethoxynaphtho[2,3-b]furan 4 showed low activity. However, parent naphtho[2,3-b]furan-4,9-dione 2 and most 2-substituted derivatives exhibited cytotoxic activity. The parent structure was therefore for cytotoxicity. 2-Formylnaphtho[2,3-b]furan-4,9-dione 11 had particularly potent activity (ED50=0.09 μg/ml).
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (4), 1009-1012, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390001206476193280
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- NII Article ID
- 10018532812
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7899972
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed