Comparisons of Potentials for L-Lysine Production among Different Corynebacterium glutamicum Strains
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<I>Corynebacterium glutamicum</I> is an industrially important organism that is most widely used for the production of various amino acids. A defined <small>L</small>-lysine-producing mutant was generated by introduction of the <I>lysC</I> mutation (T311I) into each of six representative <I>C. glutamicum</I> strains. The resulting six isogenic mutants were compared for <small>L</small>-lysine production under traditional 30 °C conditions and industrially more advantageous 40 °C conditions. It was found that there were significant differences in yield and productivity, especially at 40 °C. These results indicate the diversity among <I>C. glutamicum</I> strains in fermentative characters, as well as the importance of selecting a strain with industrially best performance.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(4), 1017-1020, 2006-04-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry