Comparisons of Potentials for<scp>L</scp>-Lysine Production among Different<i>Corynebacterium glutamicum</i>Strains

  • OHNISHI Junko
    BioFrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • IKEDA Masato
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University

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  • Comparisons of Potentials for L-Lysine Production among Different Corynebacterium glutamicum Strains

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Corynebacterium glutamicum is an industrially important organism that is most widely used for the production of various amino acids. A defined L-lysine-producing mutant was generated by introduction of the lysC mutation (T311I) into each of six representative C. glutamicum strains. The resulting six isogenic mutants were compared for L-lysine production under traditional 30 °C conditions and industrially more advantageous 40 °C conditions. It was found that there were significant differences in yield and productivity, especially at 40 °C. These results indicate the diversity among C. glutamicum strains in fermentative characters, as well as the importance of selecting a strain with industrially best performance.

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