Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin
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An anti-inflammatory triterpenoid, ursolic acid (UA), has recently been found unexpectedly to induce the release of a pro-inflammatory mediator in resting macrophages. In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-α, whereas its effect on tumor promotion was unclear.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(4), 1033-1037, 2006-04-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry