Biosynthesis of 2'-O-Methylmyxalamide D in the Myxobacterium Cystobacter fuscus : a Polyketide Synthase-Nonribosomal Peptide Synthetase System for the Myxalamide D Skeleton and a Methyltransferase for the Final O-Methylation

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The biosynthetic gene cluster for the polyene antifungal antibiotic, 2′-<I>O</I>-methylmyxalamide D, was cloned from myxobacterium <I>Cystobacter fuscus</I> AJ-13278. A sequence analysis of the 12.8-kb region in the gene cluster revealed the presence of two type I polyketide synthase genes, <I>mmxB</I> and <I>mmxC</I>. The involvement of these two genes in the biosynthesis of 2′-<I>O</I>-methylmyxalamide D was confirmed by a gene disruption experiments. In addition, an <I>S</I>-adenosylmethionine-dependent methyltransferase gene (<I>mmxM</I>) was found downstream of the gene cluster and demonstrated, by a gene disruption analysis, to be responsible for converting the known unmethylated precursor, myxalamide D, into 2′-<I>O</I>-methylmyxalamide D.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(3), 699-705, 2006-03-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018533593
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    7872260
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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