Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats
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Orally administered methanol extract of <I>Passiflora edulis</I> rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 μg/g dry weight of luteolin and 41 μg/g dry weight of luteolin-6-<I>C</I>-glucoside. It also contained γ-aminobutyric acid (GABA, 2.4 mg/g dry weight by LC-MS/MS or 4.4 mg/g dry weight by amino acid analysis) which has been reported to be an antihypertensive material. Since the extract contained a relatively high concentration of GABA, the antihypertensive effect of the extract in SHRs might be due mostly to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(3), 718-721, 2006-03-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry