Antihypertensive Effect of an Extract of<i>Passiflora edulis</i>Rind in Spontaneously Hypertensive Rats

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  • ICHIMURA Toshiaki
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST)
  • YAMANAKA Akiko
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST)
  • ICHIBA Toshio
    Okinawa Industrial Technology Center
  • TOYOKAWA Tetsuya
    Okinawa Industrial Technology Center
  • KAMADA Yasuhiro
    Okinawa Industrial Technology Center
  • TAMAMURA Takako
    Okinawa Industrial Technology Center
  • MARUYAMA Susumu
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST)

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  • Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats

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Orally administered methanol extract of Passiflora edulis rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 μg/g dry weight of luteolin and 41 μg/g dry weight of luteolin-6-C-glucoside. It also contained γ-aminobutyric acid (GABA, 2.4 mg/g dry weight by LC-MS/MS or 4.4 mg/g dry weight by amino acid analysis) which has been reported to be an antihypertensive material. Since the extract contained a relatively high concentration of GABA, the antihypertensive effect of the extract in SHRs might be due mostly to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.

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