Isomer-Specific Anti-Obese and Hypolipidemic Properties of Conjugated Linoleic Acid in Obese OLETF Rats

• WANG Yu-Ming

  Department of Applied Biological Sciences, Saga University

• NAGAO Koji

  Department of Applied Biological Sciences, Saga University

• INOUE Nao

  Department of Applied Biological Sciences, Saga University

• UJINO Yoko

  Department of Applied Biological Sciences, Saga University

• SHIMADA Yuji

  Department of Biochemistry, Osaka Municipal Technical Research Institute

• NAGAO Toshihiro

  Department of Biochemistry, Osaka Municipal Technical Research Institute

• IWATA Toshio

  Research Laboratory, The Nisshin OilliO Group, Ltd.

• KAMEGAI Takeshi

  Research Laboratory, The Nisshin OilliO Group, Ltd.

• YAMAUCHI-SATO Yoshie

  Research Laboratory, The Nisshin OilliO Group, Ltd.

• YANAGITA Teruyoshi

  Department of Applied Biological Sciences, Saga University

抄録

Conjugated linoleic acid (CLA), a mixture of positional and geometric isomers of linoleic acid, has attracted considerable attention because of its potentially beneficial biologic effects both in vitro and in vivo. Our results clearly show the specific action of the 10trans,12cis-CLA isomer against hyperlipidemia and obesity in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. After 2 weeks of feeding with 10t,12c-CLA, but not 9cis,11trans-CLA, abdominal adipose tissue weight and serum and hepatic lipid levels in OLETF rats were lower than those in linoleic acid-fed rats. These effects were attributable to suppressed fatty acid synthesis and enhanced fatty acid beta oxidation in the liver on a 10t,12c-CLA diet. Additionally, we showed that mRNA expression of fatty acid synthase, carnitine palmitoyltransferase, leptin, and sterol regulatory element binding protein-1 was also regulated by 10t,12c-CLA. We suppose that 10t,12c-CLA reveals hypolipidemic and anti-obese activity through the alteration of mRNA expressions in the liver and white adipose tissue.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 70 (2), 355-362, 2006

  公益社団法人 日本農芸化学会

キーワード

• conjugated linoleic acid isomers
• hyperlipidemia
• obesity
• Otsuka Long-Evans Tokushima Fatty rat
• sterol regulatory element binding protein-1

詳細情報

• CRID: 1390282681452467840
• NII論文ID: 10018533997
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70.355
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 7833368
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7833368
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.355
• Web Site: https://search.jamas.or.jp/link/ui/2007048535
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可