Effects of Spirulina, a Blue-Green Alga, on Bone Metabolism in Ovariectomized Rats and Hindlimb-Unloaded Mice
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- ISHIMI Yoshiko
- Division of Applied Food Research, National Institute of Health and Nutrition
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- SUGIYAMA Fumie
- Division of Applied Food Research, National Institute of Health and Nutrition
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- EZAKI Junko
- Division of Applied Food Research, National Institute of Health and Nutrition
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- FUJIOKA Maiko
- Division of Applied Food Research, National Institute of Health and Nutrition
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- WU Jian
- Division of Applied Food Research, National Institute of Health and Nutrition
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Abstract
The safety and effectiveness were examined of the spirulina alga on bone metabolism in ovariectomized estrogen-deficient rats and hindlimb-unloaded mice. The dosage range was from an amount equal to that recommended in so-called health foods for humans (0.08 g/kg BW/day) to a 100-fold higher dose. The bone mineral density (BMD) of the whole femur and tibia of ovariectomized rats in the any spirulina-treated groups was not significantly different from that of the ovariectomized group, although BMD of the distal femur and proximal tibia was significantly lower in the spirulina-treated groups than in the ovariectomized group after a 6 week-experimental period. BMD of the femur and tibia was not affected by treatment with any dose of spirulina in hindlimb-unloaded mice. These results suggest that the intake of spirulina decreased BMD in the trabecular bone of rodents under estrogen-deficient conditions.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (2), 363-368, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681452470400
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- NII Article ID
- 10018534052
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7833387
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed