Blood Pressure-Depressing Activity of a Peptide Derived from Silkworm Fibroin in Spontaneously Hypertensive Rats
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Peptides showing inhibitory activity against the angiotensin I-converting enzyme (ACE) were investigated from the fibroin fraction of discarded silk fabric. Fibroin, which was hydrolyzed with alcalase after partial hydrolysis with hot aqueous 40% CaCl<SUB>2</SUB>, released two major active peptides showing ACE-inhibitory activity. The two peptides were identified as glycyl-valyl-glycyl-tyrosine (GVGY) and glycyl-valyl-glycyl-alanyl-glycyl-tyrosine (GVGAGY) by analyses with a protein sequencer and LC/MS/MS. GVGY, whose ACE-inhibitory activity has not previously been reported, showed a blood pressure-depressing effect on spontaneously hypertensive rat (SHR).
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(2), 517-520, 2006-02-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry