Effect of Estrogens on the Interferon-.GAMMA. Producing Cell Population of Mouse Splenocytes
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- NAKAYA Mako
- Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- TACHIBANA Hirofumi
- Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- YAMADA Koji
- Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Bibliographic Information
- Other Title
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- Effect of Estrogens on the Interferon-γ Producing Cell Population of Mouse Splenocytes
- Effect of Estrogens on the Interferon ガンマ Producing Cell Population of Mouse Splenocytes
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Abstract
We examined the effect of 17β-estradiol (E2) on the cytokine production by mouse splenocytes. The production of interferon-γ (IFN-γ) was enhanced by E2 stimulation. E2 increased the number of cells expressing IFN-γ and the IFN-γ mRNA expression level in the cells. There were low- and high-level cells expressing IFN-γ in the population. The natural killer (NK) cells and NKT cells were the low-level cells expressing IFN-γ, and the number of these cells was increased by E2 stimulation. In addition, it was suggested that the enhancing effect of IFN-γ production by E2 was mediated through estrogen receptor (ER) α, and ERβ agonist stimulated IFN-γ production. ERs are expressed on plasma membrane as well as in nucleus. The ligand specific to plasma membrane-associated ER (mER) enhanced the IFN-γ production. In conclusion, our results indicated that E2 up-regulated the IFN-γ production by mediating ERα, ERβ and mERs.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (1), 47-53, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681452137344
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- NII Article ID
- 10018535015
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7791180
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed