DPPH Radical Scavenging Reaction of Hydroxy- and Methoxychalcones
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The DPPH radical scavenging activity of 2′,4′,6′-trihydroxy- and 2′-hydroxy-4′,6′-dimethoxychalcones carrying a 2,3- and 3,4-dihydroxylated, and 3,4,5-trihydroxylated B-ring was evaluated in alcoholic and non-alcoholic solvents. All test compounds scavenged more than two equivalent of radicals by a possible conversion to the corresponding B-ring quinones and in most cases subsequently underwent cyclization to aurones and flavanones, these being identified in the reaction solutions by an <I>in situ</I> NMR analysis. Interestingly, the reaction between 2′,3,4-trihydroxy-4′,6′-dimethoxychalcone and the DPPH radical was significantly affected by the solvent used, which might be accounted for by the difference in readiness for cyclization to an aurone.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(1), 193-202, 2006-01-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry