紫外線がRETチロシンキナーゼの活性制御を介して悪性黒色腫を誘導する機構 Ultraviole Irradiation-Mediated Malignant Melanoma Induction with RET Tyrosine Kinase Activation

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著者

    • 加藤 昌志 KATO Masashi
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 武田 湖州恵 TAKEDA Kozue
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 川本 善之 [他] KAWAMOTO Yoshiyuki
    • 中部大学生命健康科学部生命医科学科免疫学 Units of Immunology, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • Hossain Khaled HOSSAIN Khaled
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 大神 信孝 OHGAMI Nobutaka
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 柳下 武士 YANAGISHITA Takeshi
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 大嶋 雄一郎 OHSHIMA Yuichiro
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 加藤 容子 KATO Yoko
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 大神 恭子 OHGAMI Kyoko
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 山森 達也 YAMAMORI Tatsuya
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 立山 敬裕 TATEYAMA Keisuke
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
    • 山ノ下 理 YAMANOSHITA Osamu
    • 中部大学生命健康科学部生命医科学科環境衛生学 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University

抄録

We previously established a <i>RET</i>-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the <i>RET</i>-transgenic mice of line 304/B6. We also established another <i>RET</i>-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the <i>RET</i>-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.

収録刊行物

  • 日本衞生學雜誌  

    日本衞生學雜誌 62(1), 3-8, 2007-01-15 

    日本衛生学会

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各種コード

  • NII論文ID(NAID)
    10018539294
  • NII書誌ID(NCID)
    AN00185923
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    00215082
  • NDL 記事登録ID
    8689352
  • NDL 雑誌分類
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL 請求記号
    Z19-194
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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