Ultraviole Irradiation-Mediated Malignant Melanoma Induction with RET Tyrosine Kinase Activation

DOI Web Site Web Site 25 References
  • KATO Masashi
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • TAKEDA Kozue
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • KAWAMOTO Yoshiyuki
    Units of Immunology, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • HOSSAIN Khaled
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • OHGAMI Nobutaka
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • YANAGISHITA Takeshi
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University Department of Dermatology, Aichi Medical University School of Medicine
  • OHSHIMA Yuichiro
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University Department of Dermatology, Aichi Medical University School of Medicine
  • KATO Yoko
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • OHGAMI Kyoko
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • YAMAMORI Tatsuya
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • TATEYAMA Keisuke
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • YAMANOSHITA Osamu
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University

Bibliographic Information

Other Title
  • 紫外線がＲＥＴチロシンキナーゼの活性制御を介して悪性黒色腫を誘導する機構
  • シガイセン ガ RET チロシンキナーゼ ノ カッセイ セイギョ オ カイシテ アクセイ コクショク シュ オ ユウドウ スル キコウ

Search this article

Abstract

We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.

Journal

References(25)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top