毒性研究におけるゲノム技術等の現状と課題 Advances in "Omics" Technologies for Toxicological Research

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Toxicology research can be applied to evaluate potential human health risks resulting from exposure to chemicals and other factors in the environment. The tremendous advances that have been made in high-throughput "omics" technologies (e.g., genomics, transcriptomics, proteomics and metabolomics) are providing good tools for toxicological research. Toxicogenomics is the study of changes in gene expression, protein and metabolite profiles, and combines the tools of traditional toxicology with those of genomics and bioinformatics. In particular, identification of changes in gene expression using DNA microarrays is an important method for understanding toxicological processes and obtaining an informative biomarker. Although these technologies have emerged as a powerful tool for clarifying hazard mechanisms, there are some concerns for the application of these technologies to toxicological research. This review summarizes the impact of "omics" technologies in toxicological study, followed by a brief discussion of future research.

収録刊行物

  • 日本衞生學雜誌  

    日本衞生學雜誌 62(1), 18-31, 2007-01-15 

    日本衛生学会

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各種コード

  • NII論文ID(NAID)
    10018539329
  • NII書誌ID(NCID)
    AN00185923
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    00215082
  • NDL 記事登録ID
    8689395
  • NDL 雑誌分類
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL 請求記号
    Z19-194
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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