Warfarin-induced Skin Necrosis and Venous Limb Gangrene: Lesson from a Case Induced the Serious Complications by the Anticoagulants During the Treatment of Acute Artery Occlusion

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  • Kishida Ken
    Department of Cardiology, Rinku General Medical Center, Izumisano Hospital
  • Nakatsuji Hideaki
    Department of Cardiology, Rinku General Medical Center, Izumisano Hospital
  • Nagai Yoshiyuki
    Department of Cardiology, Rinku General Medical Center, Izumisano Hospital

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  • 抗凝固剤ワルファリンによる皮膚壊死および静脈性四肢壊疽―急性動脈閉塞症の治療中に抗凝固剤による重大な副作用を起こした1例から学ぶ―

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Abstract

<p>Both heparin and warfarin are used extensively for the treatment and prophylaxis of thromboembolism as the anticoagulants in medical and surgical practice. At the point of using these anticoagulants, it is taken particular care to a relative high frequent complication, as hemorrhage easily. However, what happens is that it is not known further complication. We reported a patient whose clinical course suggested that the immune-mediated heparin-induced thrombocytopenia during the treatment of acute artery occlusion associated with the gastric cancer might be a risk factor for the development of warfarin-induced skin necrosis. Failure of early diagnosis and treatment may result in death. Many reviews have now been given a complete description of heparin-induced thrombocytopenia. In this paper, we comment on the thrombolytic complications of venous limb gangrene and warfarin-induced skin necrosis as the serious side effects that all clinicians should be aware of these existences, although its precise pathogenesis is still unclear.</p>

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