再発鼻腔悪性黒色腫に対する細胞免疫療法 Autologous Tumor-specific Immunotherapy for Recurrent Malignant Melanoma of the Nasal Cavity

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著者

    • 坂本 菊男 SAKAMOTO Kikuo
    • 久留米大学医学部耳鼻咽喉科 Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
    • 高根 陽子 TAKANE Youko
    • 久留米大学医学部耳鼻咽喉科 Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
    • 前田 明輝 MAEDA Akiteru
    • 久留米大学医学部耳鼻咽喉科 Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
    • 宮嶋 義巳 MIYAJIMA Yoshimi
    • 久留米大学医学部耳鼻咽喉科 Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
    • 中島 格 NAKASHIMA Tadashi
    • 久留米大学医学部耳鼻咽喉科 Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine

抄録

鼻腔悪性黒色腫の集学的治療後約7年経過して局所再発と縦隔リンパ節転移を認めた症例に対し,細胞傷害性Tリンパ球(CTL)による局所免疫療法と全身的免疫療法を施行して進行を制御できた症例を報告した.症例は45歳女性.1996年10月鼻腔腫瘍で当科を受診した.鼻腔悪性黒色腫の診断で集学的治療を施行した.経過観察中,2003年10月に局所再発した.化学療法で粘膜病変はNCのためCTLの局所注入療法を行った.現在までに23回施行し局所粘膜病変は徐々に消退している.また,経過中に縦隔リンパ節転移を認め経静脈的にCTLを投与した.現在までに15回施行し,CT上著変認めず進行を制御している.

Malignant melanoma usually occurs in tissues containing large numbers of melanocytes, such as the skin, mucosa and eye, and is one of the most highly malignant tumors known. No satisfactory treatment results have ever been reported. We report here an effective course of immunotherapy consisting of the local injection and intra-venous administration of autologous tumor-cell-stimulated cytotoxic T lymphocytes in a patient with recurrent malignant melanoma. The patient was a 45-year-old woman. She had been diagnosed as having malignant melanoma in 1996 and under went radio-chemotherapy at our hospital. Seven years later, recurrences were recognized in bilateral nasal cavities. Following systematic chemotherapy, 23 local injections of cytotoxic T lymphocytes were performed. Mediastinal lymphonode metastasis was recognized in March, 2004, so 15 additional intravenous administrations of cytotoxic T lymphocytes were performed. At present, no obvious regrowth has been recognized. Immunotherapy using cytotoxic T lymphocytes may be a useful strategy for controlling recurrent malignant melanoma.

収録刊行物

  • 日本耳鼻咽喉科學會會報  

    日本耳鼻咽喉科學會會報 109(11), 781-784, 2006-11-20 

    The Oto-Rhino-Laryngological Society of Japan, Inc.

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各種コード

  • NII論文ID(NAID)
    10018561610
  • NII書誌ID(NCID)
    AN00191551
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00306622
  • NDL 記事登録ID
    8583944
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-250
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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