Potential for Immunological and Microbiological Intervention against <i>Porphyromonas gingivalis</i> Infection
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- Hajishengallis George
- Center for Oral Health and Systemic Disease, Departments of Periodontics/Endodontics and of Microbiology/Immunology, University of Louisville School of Dentistry
Bibliographic Information
- Other Title
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- Potential for Immunological and Microbiological Intervention against Porphyromonas gingivalis Infection
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Abstract
The presence of Porphyromonas gingivalis is strongly correlated with chronic periodontitis, an oral infection-driven inflammatory disease. Both bacterial virulence factors and host factors contribute to periodontal tissue destruction, including inflammatory resorption of alveolar bone which may lead to tooth loss. P. gingivalis can successfully colonize subgingival areas, induces inflammatory reactions by host immune cells, but is believed to resist immune elimination. This article reviews important virulence factors and mechanisms that allow P. gingivalis to thrive in the periodontium, and summarizes potential microbiological and immunological intervention strategies to counteract P. gingivalis pathogenesis.
Journal
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- Journal of Oral Biosciences
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Journal of Oral Biosciences 49 (1), 1-14, 2007
Japanese Association for Oral Biology
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Details 詳細情報について
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- CRID
- 1390001205213436672
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- NII Article ID
- 130004475631
- 10018562671
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- NII Book ID
- AA11896386
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- ISSN
- 18803865
- 13490079
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed