メチレン化反応の推移 : 鍋の中身の結末 [in Japanese] Transition of Methylenation Reaction : The Outcome of "Ingredients of Couldron" [in Japanese]
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In 1978, Nozaki, Oshima, and Takai reported that CH<SUB>2</SUB>X<SUB>2</SUB>-Zn-TiCl<SUB>4</SUB> reagent is effective for Wittig-type methylenation of carbonyl compounds. We investigated this reagent system in detail and concluded that CH<SUB>2</SUB> (ZnI) <SUB>2</SUB> and β-TiCl<SUB>3</SUB> are real reactive species. Chemoselective methylention using dizinc reagent is also shown.
- J. Synth. Org. Chem. Jpn.
J. Synth. Org. Chem. Jpn. 65(3), 194-203, 2007-03-01
The Society of Synthetic Organic Chemistry, Japan