A hepatocellular carcinoma developed following 12 years from sustained virologic response to interferon therapy in a patient with hepatitis C

• Kawano Youichi

  Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School

• Egami Kaku

  Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School

• Sasajima Koji

  Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School

• Miyamoto Masayuki

  Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School

• Yokoyama Tadashi

  Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School

• Maeda Shotaro

  Department of Pathology, Tama-Nagayama Hospital, Nippon Medical School

• Yoshida Hiroshi

  First Department of Surgery, Nippon Medical School

• Mamada Yasuhiro

  First Department of Surgery, Nippon Medical School

• Taniai Nobuhiko

  First Department of Surgery, Nippon Medical School

• Tajiri Takashi

  First Department of Surgery, Nippon Medical School

Bibliographic Information

Other Title

• Ｃ型慢性肝炎に対するインターフェロン療法著効１２年後に発症した破裂肝細胞癌の１切除例
• 症例報告 C型慢性肝炎に対するインターフェロン療法--著効12年後に発症した破裂肝細胞癌の1切除例
• ショウレイ ホウコク Cガタ マンセイ カンエン ニ タイスル インターフェロン リョウホウ チョコウ 12ネンゴ ニ ハッショウシタ ハレツ カン サイボウ ガン ノ 1 セツジョレイ

Abstract

We successfully resected hepatocellular carcinoma (HCC) that developed 12 years after the achievement of sustained virologic response (SVR) to interferon (IFN) therapy in a 65-year-old man with an unknown transmission route of hepatitis C virus (HCV). In 1992, he was found to have chronic hepatitis C and treated by IFN-β and after which, SVR was obtained. Twelve years after therapy, he reported sudden abdominal pain. CT led to a diagnosis of ruptured HCC of segment 7, necessitating emergency hepatic arterial embolization, followed by hepatic S7 subsegmentectomy. He recovered without complications. This case showed the longest period from achievement of SVR to development of HCC carcinogenesis among those reported in Japan, and features poorly differentiated HCC, carcinogenesis from the eradicated fibrosis liver by IFN therapy with numerous positive cells stained by Mib-1. In conclusion, close observation is required for patients who obtained SVR of HCV even after 10 years.<br>

Journal

• Kanzo

  Kanzo 48 (2), 48-56, 2007

  The Japan Society of Hepatology

Keywords

• chronic hepatitis type C
• interferon therapy
• hepatocellular carcinoma
• carcinogenesis
• sustained virologic response

Details

• CRID: 1390001204789953024
• NII Article ID: 10018587107
• NII Article ID: 20000638447
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.48.48
• ISSN: 18813593
• ISSN: 04514203
• NDL BIB ID: 8729120
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8729120
• Web Site: http://www.jstage.jst.go.jp/article/kanzo/48/2/48_2_48/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007179185
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed