Impaired mitochondrial β-oxidation in chronic hepatitis C patients, evidenced by fasting test

• Misawa Keiko

  Department of Gastroenterology, Yamagata University Faculty of Medicine

• Saito Takafumi

  Department of Gastroenterology, Yamagata University Faculty of Medicine

• Sugahara Kazuhiko

  Department of Gastroenterology, Yamagata University Faculty of Medicine

• Saito Koji

  Department of Gastroenterology, Yamagata University Faculty of Medicine

• Togashi Hitoshi

  Department of Gastroenterology, Yamagata University Faculty of Medicine

• Kawata Sumio

  Department of Gastroenterology, Yamagata University Faculty of Medicine

Bibliographic Information

Other Title

• Ｃ型慢性肝炎患者における脂肪酸β酸化障害―絶食試験を用いた検討―

Abstract

Impaired mitochondrial β-oxidation by HCV core protein causes hepatic steatosis in hepatitis C patients. We assessed mitochondrial β-oxidation and HCV core antigenemia in six patients with chronic hepatitis C by detecting serum concentrations of total ketone bodies, triglyceride, and HCV core protein. All but one (5/6) patients showed significantly lower level of total ketone bodies than normal controls at 15 hours after the start of fasting test (170.6±158.4 vs 370.6±70.2 μmol/L, p<0.05). The result suggests that impaired mitochondrial β-oxidation exists in some or most of hepatitis C patients.<br>

Journal

• Kanzo

  Kanzo 48 (2), 85-86, 2007

  The Japan Society of Hepatology

Keywords

• HCV
• β-oxidation
• ketone body

Details

• CRID: 1390282679766657408
• NII Article ID: 10018587228
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.48.85
• ISSN: 18813593
• ISSN: 04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo/48/2/48_2_85/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007179190
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed