肝細胞癌治療に関するRCTの質評価 : 日本発RCTの問題点 Quality assessment of randomized controlled trials in the treatment of hepatocellular carcinoma

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This study evaluated the quality of randomized controlled trials (RCTs) involving the treatment of hepatocellular carcinoma (HCC). A MEDLINE search was performed to identify prospective RCTs investigating HCC treatment published between 1991 and 2005. Eligible RCTs were evaluated by grading 5 items including sample size, calculation of sample size, intention to treat analysis, mean observational period, and loss to follow-up rate.<br> Seventy-five papers were eligible for analysis. Geographically, more than half of these RCTs were performed in Asia and the most papers were published by Japan. However, the quality of RCTs from Japan was the lowest in the top five countries. Improvement of internal validity with adequate study design is important to obtain reliable evidence.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 48(1), 33-35, 2007-01-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10018587319
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • NDL 記事登録ID
    8613008
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z19-130
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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