Quality assessment of randomized controlled trials in the treatment of hepatocellular carcinoma

• Kaido Toshimi

  Department of Surgery, Otsu Municipal Hospital

Bibliographic Information

Other Title

• 肝細胞癌治療に関するＲＣＴの質評価―日本発ＲＣＴの問題点―
• カン サイボウガン チリョウ ニ カンスル RCT ノ シツ ヒョウカ ニホンハツ RCT ノ モンダイテン

Abstract

This study evaluated the quality of randomized controlled trials (RCTs) involving the treatment of hepatocellular carcinoma (HCC). A MEDLINE search was performed to identify prospective RCTs investigating HCC treatment published between 1991 and 2005. Eligible RCTs were evaluated by grading 5 items including sample size, calculation of sample size, intention to treat analysis, mean observational period, and loss to follow-up rate.<br> Seventy-five papers were eligible for analysis. Geographically, more than half of these RCTs were performed in Asia and the most papers were published by Japan. However, the quality of RCTs from Japan was the lowest in the top five countries. Improvement of internal validity with adequate study design is important to obtain reliable evidence.<br>

Journal

• Kanzo

  Kanzo 48 (1), 33-35, 2007

  The Japan Society of Hepatology

Keywords

• hepatocellular carcinoma
• RCT
• quality assessment

Details

• CRID: 1390001204790834432
• NII Article ID: 10018587319
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.48.33
• ISSN: 18813593
• ISSN: 04514203
• NDL BIB ID: 8613008
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8613008
• Web Site: http://www.jstage.jst.go.jp/article/kanzo/48/1/48_1_33/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007114095
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed