書誌事項
- タイトル別名
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- The effect of short term nasal CPAP therapy in cases of obstructive sleep apnea syndrome.
抄録
Recent studies have shown that nasal CPAP is very effective in the treatment of patients with obstructive sleep apnea syndrome (OSA). To clarify the characteristics of pulmonary function testing and to evaluate the effect of short term nasal CPAP therapy in 13 cases of OSA patients, nasal CPAP was used for 10 to 14 days and polysomnography was performed on two consecutive nights without nasal CPAP and at one night with nasal CPAP. Pulmonary function tests and the Uchida-Kraepelin test were performed before the initiation of nasal CPAP therapy and also 7 to 14 days after the nasal CPAP therapy. Apnea index reduced significantly in all cases from 51.0±19.6 episodes/hour without therapy to 3.1±3.5 with nasal CPAP (p<0.001). Nasal CPAP significantly reduced the frequency of obstructive (p<0.001) and mixed apnea (p<0.01), but the frequency of central apnea did not change with nasal CPAP. During the nasal CPAP, mean nadir SaO2 rose from 87.3±2.9% to 92.7±1.1% (p<0.001) and the lowest SaO2 rose from 73.3±6.4% to 92.0±2.1% (p<0.001). Before the nasal CPAP therapy, daytime PaO2 was 80.6±6.4 Torr and closing capacity (CC)/FRC ratio was higher when patients were in a supine than in a sitting position. After short term nasal CPAP therapy, daytime PaO2 increased significantly (p<0.001), and FRC/TLC in a supine position increased and CC/FRC in a supine position decreased in some patients. It can be postulated that the increase in daytime PaO2 associated with short term nasal CPAP therapy can be attributed, at least in part, to an increase in FRC and also to the reduction of CC/FRC. The Uchida-Kraepelin test revealed significant increment of average result after short term treatment of nasal CPAP (p<0.001). We conclude that nasal CPAP therapy during sleep is an effective and non invasive therapy for patients of OSA, and may lead to rapid recovery of mental function after short term treatment.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 28 (5), 698-705, 1990
社団法人 日本呼吸器学会