Histopathological, Immunopathological and Electron Microscopic Studies on Pig Liver Inoculated with Pasteurella multocida Dermonecrotic Toxin

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著者

    • ARAI Yasuko
    • Research Center for Veterinary Science of The Kitasato Institute
    • IKE Kazunori
    • Research Center for Veterinary Science of The Kitasato Institute
    • OYAMADA Toshifumi
    • Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
    • YOSHIKAWA Hiroyasu
    • Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
    • YOSHIKAWA Takashi
    • Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
    • KUME Katsumi
    • Research Center for Veterinary Science of The Kitasato Institute

抄録

Dermonecrotic toxin (DNT) produced by <i>Pasteurella multocida</i> was purified by anion-exchange chromatography, gel filtration, and high-performance liquid chromatography. Pigs were given an intramuscular injection of <i>P.multocida</i> dermonecrotic toxin (Pm-DNA), which produced necrotic lesions of the liver. Liver sections were taken at intervals of 2, 12, and 24 hours after Pm-DNA injection. We examined the sections histopathologically, immunopathologically, and electron microscopically. The earliest alterations observed were loss of glycogen from hepatocytes, which became more severe during later intervals, vacuolation and single-cell necrosis of hepatocytes, as well as desquamation and fragmentation of the sinusoidal endothelium. The vacuoles subsequently increased in quantity and size with the passage of time and found to contain homogeneous fine material and/or fibrillar material. These materials were thought to be fibrin and blood serum. The vacuoles penetrated the cytoplasm of the hepatocytes. We considered that liver necrosis caused by Pm-DNT probably resulted from the principal effects of vascular injury, although the membrane of the hepatocytes was more or less damaged by the toxin.

収録刊行物

  • Journal of toxicologic pathology  

    Journal of toxicologic pathology 11(2), 109-117, 1998-06-01 

    JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

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各種コード

  • NII論文ID(NAID)
    10018611047
  • NII書誌ID(NCID)
    AA12022786
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09149198
  • データ提供元
    CJP書誌  J-STAGE 
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