口腔扁平上皮癌における細胞外基質への初期浸潤分子機構 Molecular mechanism of initial stage of extracellular matrix invasion of oral squamous cell carcinoma

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著者

    • 大谷 朋弘 OTANI Tomohiro
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
    • 中原 寛和 NAKAHARA Hirokazu
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
    • 三浦 康寛 MIURA Yasuhiro
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
    • 松岡 裕大 MATSUOKA Yudai
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
    • 山西 整 YAMANISHI Tadashi
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
    • 上田 貴史 UEDA Takashi
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
    • 能崎 晋一 NOZAKI Sin-ichi
    • 金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野(歯科口腔外科学講座) Oral and Maxillofacial Surgery, Department of Cell and Tissue Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science
    • 田中 彰 TANAKA Akira
    • 金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野(歯科口腔外科学講座) Oral and Maxillofacial Surgery, Department of Cell and Tissue Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science
    • 山本 悦秀 YAMAMOTO Etsuhide
    • 金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野(歯科口腔外科学講座) Oral and Maxillofacial Surgery, Department of Cell and Tissue Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science
    • 古郷 幹彦 KOGO Mikihiko
    • 大阪大学大学院歯学研究科顎口腔病因病態制御学講座(口腔外科学第一教室) The First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry

抄録

Invadopodia are membrane protrusions into the extracellular matrix by aggressive tumor cells. Through reorganization of the actin cytoskeleton, these structures are associated with sites of matrix degradation and invasiveness of malignant tumor cells in an in vitro fibronectin degradation/invasion assay. In this study, we examined cell morphology and invasive activity for three cell lines derived from human oral squamous cell carcinomas with different invasive modes. According to Yamamoto-Kohama's classification, OSC-20 was classified as grade 3, OSC-19 as grade 4C, and HOC313 as grade 4D. OSC-20 and OSC-19 showed pavement stone patterns, and HOC313 showed a fibroblast-like cell pattern. OSC-19 and HOC313 showed dot-like degradation in the in vitro fibronectin degradation/invasion assay, whereas OSC-20 showed diffuse-type degradation. Our results suggest that reorganization of the actin cytoskeleton and cell shape are related to the invasiveness of oral squamous carcinoma cells.

収録刊行物

  • 日本口腔外科学会雑誌

    日本口腔外科学会雑誌 50(12), 741-748, 2004-12-20

    Japanese Society of Oral and Maxillofacial Surgeons

参考文献:  25件中 1-25件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10018618510
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00215163
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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